Papel da tireoglobulina sérica no seguimento de pacientes com carcinoma diferenciado da tireoide
| dc.contributor.advisor | Mattevi, Vanessa Suñé | pt_BR |
| dc.contributor.advisor-co | Meyer, Erika Laurini de Souza | pt_BR |
| dc.contributor.author | Jaeger, Fabiana | pt_BR |
| dc.contributor.department | Programa de Pós-Graduação em Patologia | pt_BR |
| dc.date.accessioned | 2026-08-22T13:12:45Z | |
| dc.date.date-insert | 2026-08-22 | |
| dc.date.issued | 2023-08-11 | |
| dc.description | Dissertação (Mestrado) - Programa de Pós-Graduação em Patologia, Fundação Universidade Federal de Ciências da Saúde de Porto Alegre. | pt_BR |
| dc.description.abstract | Introdução: A tireoglobulina (Tg) sérica tem papel na avaliacao do risco de persistencia/recorrencia tumoral e resposta a terapia no CDT. Objetivo: Correlacionar os níveis de tireoglobulina estimulada pré-radioiodoterapia (pré-RIT Tg) e a avaliação de resposta ao tratamento, e definir um valor da pré-RIT Tg preditora de excelente resposta. Materiais e Métodos: Coorte observacional, retrospectiva, com 166 pacientes com CDT submetidos a tireoidectomia e radioiodoterapia. Os níveis da pré-RIT Tg foram comparados conforme a resposta a terapia inicial. Analisamos a curva ROC e estabelecemos um ponto de corte. Resultados: A pré-RIT Tg foi diferente entre as diferentes respostas a terapia (p < 0,001) foram associados a RE. Na análise multivariada, ATA baixo risco (RR 1,61, IC 95% 1,06-2,44, p 0,02) e pré-RAI Tg ≤6,14ng/dL (RR 2,09, IC 95% 1,5-2,92, p <0,001) foram associados a RE. Após 7,4 anos de seguimento (3,5-10 anos), 124 (74,7%) pacientes encontraram-se no grupo ER, 22 (13,2%) pacientes no IndR e 20 (12%) pacientes no IncR. Conclusão: Nossos resultados sugerem que a pré-RIT Tg prediz a avaliação de resposta inicial ao tratamento. A pré-RIT Tg (≤ 6,14ng/dL) foi preditora de desfechos clínicos em pacientes com CDT. | pt_BR |
| dc.description.abstract-en | Introduction: Serum thyroglobulin has an important role in evaluating risks of persistent/recurrent disease and response to therapy in DTC. Objective: To correlate pre-RAI Tg levels and the evaluation to therapy, and to define a cut-off level for pre-RAI Tg as a predictor of excellent response. Design Retrospective cohort study of 166 DTC patients submited to total thyroidectomy and radioiodine. Pre-RAI Tg levels were compared according to response to initial therapy. A ROC curve analysis was performed, and a cutt-off point was established. Results: Pre-RAI Tg levels were distributed differently in different responses to therapy(p <0.001). The ER had a significantly lower pre-RAI Tg in comparison to IndR (p<0.001) and IncR (P<0.001), and pre-RAI Tg were different between the IndR and IncR (p=0.02). ROC analysis demonstrated that pre-RAI Tg ≤6,14 ng/dl was predictive of excellent response to therapy (AUC 0.808, CI95% 0.74-0.87), 75.7% sensitivity and 74.6% specificity. In univariate analysis, female sex (RR 1.77; IC 95% 1.04-3.0, p 0.03), ATA low-risk (RR 2.23, IC 95% 1.39-3.6, p 0.001) and intermediate-risk (RR 1.77, IC95% 1.09-2.88, p 0.02) and Tg under 6.14ng/mL (RR 2.39, IC 95% 1.72-3.32, p <0.001) as predictors of excellent response. In multivariate analysis, ATA low-risk (RR 1.61, IC 95% 1.06-2.44, p 0.02) and Tg below 6.14ng/mL (RR 2.09, IC 95% 1.5-2.92, p <0.001) were associated with excellent response. After 7.4 years median follow-up, 124 (74.7%) patients were allocated in ER, 22 (13.2%) in IndR, and 20 (12%) in IncR. Conclusion: Our results suggest that pre-RAI Tg predicts first therapy evaluation and response to treatment. Pre-RAI Tg cut-off was a key predictor of clinical outcomes in DTC patients. | en |
| dc.identifier.uri | https://repositorio.ufcspa.edu.br/handle/123456789/3579 | |
| dc.language.iso | pt_BR | pt_BR |
| dc.relation.requires | TEXTO - Adobe Reader | pt_BR |
| dc.rights | Acesso Aberto Imediato | pt_BR |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/br/ | |
| dc.subject | Neoplasias da Glândula Tireoide | pt_BR |
| dc.subject | Tireoglobulina | pt_BR |
| dc.subject | Resultado do Tratamento | pt_BR |
| dc.subject | Prognóstico | pt_BR |
| dc.subject | [en] Thyroid Neoplasms | en |
| dc.subject | [en] Thyroglobulin | en |
| dc.subject | [en] Treatment Outcome | en |
| dc.subject | [en] Prognosis | en |
| dc.subject.ods | 3 – Saúde e Bem-Estar | pt_BR |
| dc.title | Papel da tireoglobulina sérica no seguimento de pacientes com carcinoma diferenciado da tireoide | pt_BR |
| dc.type | Dissertação | pt_BR |
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